If you’ve experienced restless leg syndrome (RLS) during perimenopause, you’re not alone. Many menopause women find themselves lying awake at night with an uncontrollable urge to move their legs. This uncomfortable sensation, often worse in the evening, can make it almost impossible to get restful sleep.
Known medically as Willis Ekbom disease, restless legs syndrome is a neurological condition that affects millions worldwide, with women being more prone than men. Symptoms often appear or worsen during the menopausal transition, suggesting a strong link between hormone changes and restless leg syndrome.
This article explains the connection, common causes such as iron deficiency, and practical steps for finding temporary relief.

What Is Restless Leg Syndrome (RLS)?
Restless legs syndrome (RLS), also called Willis Ekbom disease, causes unpleasant sensations in the legs, accompanied by an overwhelming urge to move.
Typical sensations include:
- Tingling, crawling, or itching under the skin
- Throbbing or aching in the muscles
- Creeping or pulling feelings that ease with movement
Symptoms usually worsen in the evening and improve with walking or stretching. This constant restlessness can lead to:
- Daytime fatigue
- Irritability and poor concentration
- Anxiety about sleep
Women are almost twice as likely as men to develop RLS, particularly during perimenopause and menopause.
Perimenopause and Hormonal Changes
Perimenopause marks the years leading up to menopause, usually beginning in the 40s. Hormonal fluctuations in oestrogen and progesterone can cause typical menopause symptoms such as hot flushes, sleep problems, mood swings, and fatigue.
Because oestrogen interacts with dopamine (a neurotransmitter involved in movement), hormonal shifts can disrupt this balance and trigger restless leg symptoms. Many menopause women find they start developing restless legs syndrome for the first time during this phase.
Why Restless Legs Syndrome Can Develop During Perimenopause
Several physical and hormonal factors increase the likelihood of developing restless legs syndrome during perimenopause.
1. Hormonal Fluctuations and Dopamine
Oestrogen and progesterone changes can disturb dopamine function, leading to uncomfortable leg sensations and the urge to move. Low dopamine activity is one of the main features of Willis Ekbom disease.
2. Iron Deficiency
Iron is essential for brain and nerve function. Even mild iron deficiency can worsen restless legs syndrome RLS. During perimenopause, hormonal changes, heavy periods, or diet shifts can reduce iron levels, intensifying symptoms.
3. Vitamin and Mineral Imbalances
Deficiencies in magnesium, vitamin D, and vitamin B12 can affect nerve health and increase muscle tension. Supporting these vitamins and minerals often helps reduce symptoms and improve sleep quality.
4. Stress, Sleep Loss, and Anxiety
Poor sleep and high stress, both common menopause symptoms, can make RLS worse. Elevated cortisol levels heighten nervous system sensitivity, increasing leg restlessness at night.
5. Medications and Lifestyle
Some medications such as antidepressants and antihistamines may trigger RLS. Caffeine, alcohol, nicotine, and lack of exercise can also contribute to symptoms.
Managing Restless Legs Syndrome During Perimenopause
Restless leg syndrome can usually be managed with small lifestyle adjustments and medical guidance.
1. Check for Iron Deficiency
Ask your GP to test your ferritin and iron levels. Iron-rich foods include spinach, beans, and lean red meat. Always seek medical advice before taking supplements.
2. Replenish Vitamins and Minerals
Ensure adequate magnesium, vitamin D, and B12 intake. A balanced diet and supplements (if prescribed) can provide temporary relief from restless legs syndrome RLS.
3. Improve Sleep Hygiene
Keep a regular bedtime, avoid caffeine after midday, and create a relaxing routine with stretching, warm baths, or meditation. A cool, dark bedroom can help you fall asleep more easily.
4. Exercise Regularly
Gentle daily movement such as walking, yoga, or swimming improves circulation and dopamine levels. Avoid strenuous activity just before bed.
5. Review Medications
If symptoms started after a new prescription, speak to your GP about alternatives. Never stop or change medication without medical advice.
6. Explore Hormone Therapy
Some menopause women find Hormone Replacement Therapy (HRT) helps balance hormones and ease symptoms. Discuss suitability with your doctor.
When to See a Doctor
If symptoms persist or affect your quality of life, seek medical advice. Long-term Willis Ekbom disease can sometimes be linked to:
- Iron deficiency anaemia
- Thyroid or kidney issues
- Peripheral neuropathy
Your GP may recommend blood tests or specialist referral. In some cases, medication to stabilise dopamine or nerve activity may help.
The Bottom Line
Restless leg syndrome and perimenopause often occur together. Hormonal changes, iron deficiency, and vitamin and mineral imbalances can all play a role. The good news is that with the right lifestyle adjustments and medical support, most women can reduce discomfort and enjoy better sleep.
If you’re struggling with the urge to move your legs at night, speak with your GP, check your iron and vitamin levels, and make small changes to support your health during this transition.
